![]() ![]() "We recruited 10 patients for the study and transplanted their own stem cells into the affected knee joints, then followed up with MRIs over the next five years. Mitsuru Mizuno, DVM, Ph.D., assistant professor with CSCRM, served as the study's lead investigator. D., director and professor of the Center for Stem Cell and Regenerative Medicine (CSCRM) at Tokyo Medical and Dental University. That's what we wanted to learn from this study," said corresponding author Ichiro Sekiya, M.D., Ph. However, the safety of these cells after transplantation has not been investigated. ![]() The detection of trisomy 7 in epithelial cells has been associated with tumor formation. "Trisomy 7 occurs frequently in patients with severe knee disease such as osteoarthritis. In particular, they wanted to investigate the safety of any MSCs that might show a type of chromosomal disorder called trisomy 7. #Stem cell treatment for knees osteoarthritis freeTheir ability to secrete biologically active molecules that exert beneficial effects on injured tissues makes them a promising target in regenerative medicine.īut some stem cell treatments have been known to cause tumors, which is why the team wanted to ensure that their therapy was free of any negative side effects. MSCs are multipotent adult stem cells present in the umbilical cord, bone marrow, fat, dental and other body tissues. The team behind the current study, which included researchers from Tokyo Medical and Dental University, Kyoto University and Kazusa DNA Research Institute, recently developed a therapy involving the transplantation of MSCs derived from the knee's soft tissue (the synovium) into the injured meniscus. ![]() However, though rare, such surgery does come with risks such as the possibility of infection.Ĭellular therapies are showing great potential as a less invasive way to treat difficult-to-heal knee injuries. Knee replacement surgery is the gold standard of treatment, with the majority of people experiencing a dramatic reduction in pain and, thus, improvement in their ability to live a normal life. Along with pain, which can be debilitating, knee problems can significantly affect the person's mobility and quality of life. Osteoarthritis is the most common cause of this condition in people aged 50 and older. Age-related damage to the meniscus often leads to the progression of osteoarthritis of the knee.Ĭhronic knee pain is a major issue for the aging, affecting approximately 25 percent of all adults, according to the Centers for Disease Control and Prevention (CDC). The meniscus is a crescent-shaped cartilage in the knee joint that plays a role in shock absorption. The results showed that five years after transplantation, osteoarthritis-related tears to the knee meniscus had healed and, just as importantly, none of the patients experienced any serious side effects from the treatment. ![]()
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